Endotoxin
نویسندگان
چکیده
منابع مشابه
Ignoring endotoxin
In 1947, Paul Beeson showed that rabbits repeatedly injected with certain bacteria eventually become resistant to the bacteria's fever-provoking effects-a phenomenon known as endotoxin tolerance.
متن کاملEndotoxin receptor site. II. Specificity of endotoxin receptor of platelets and sensitivity to endotoxin in vivo.
The biological specificity of the endotoxin receptor on platelet membranes was examined. The binding indices of platelets in experimental endotoxemia which was induced by intravenous administration of endotoxin (Lipopolysaccharide of E. coli, Difco) to rabbits were found to be 30% of the control at 60 min after the injection. The result suggests that the endotoxin receptor of platelets was alre...
متن کاملEndotoxin-neutralizing protein protects against endotoxin-induced endothelial barrier dysfunction.
Bacterial lipopolysaccharide induces tyrosine phosphorylation of paxillin, actin reorganization, and opening of the transendothelial paracellular pathway through which macromoles flux. In this study, lipid A was shown to be the bioactive portion of the lipopolysaccharide molecule responsible for changes in endothelial barrier function. We then studied whether endotoxin-neutralizing protein, a r...
متن کاملIn vivo endotoxin tolerance
Endotoxin tolerance is defined as a reduced responsiveness to a lipopolysaccharide (LPS) challenge following a first encounter with endotoxin. Endotoxin tolerance protects against a lethal challenge of LPS and prevents infection and ischemia-reperfusion damage. Endotoxin tolerance is paralleled by a dramatic reduction of tumor necrosis factor (TNF) production and some other cytokines in respons...
متن کاملEndotoxin in meningococcal infections.
26 children with meningococcal infections were studied to find out the relationaship between plasma and cerebrospinal fluid levels of endotoxin, the clinical outcome, the level of antigen in plasma and cerebrospinal fluid, and indices of complement activation and disseminated intravascular coagulation. No association was found between endotoxin levels and the other factors. A high cerebrospinal...
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ژورنال
عنوان ژورنال: Critical Care Medicine
سال: 2016
ISSN: 0090-3493
DOI: 10.1097/ccm.0000000000001440